ABRAMOV PHOSPHORYLATION
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| ABRAMOV PHOSPHORYLATION REACTION |
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| ABRAMOV PHOSPHORYLATION DISCONNECTION |
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| ABRAMOV PHOSPHORYLATION MECHANISM |
NOTES :
The O-benzylated glycal is oxidatively cleaved to the aldehyde sugar bearing a formate ester at C-5. This carbon atom is originally the anomeric carbon atom. The condensation with trimethyl phosphite in glacial acetic acid or with dimethyl phosphonate under basic conditions introduces the dimethylphosphonyl moiety. See also Arbuzov (Michaelis – Arbuzov), Michaelis – Becker – Nylén and Perkow reactions.
ACHMATOWICZ PYRANONE REACTION
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| ACHMATOWICZ PYRANONE REACTION |
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| ACHMATOWICZ PYRANONE MECHANISM |
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| ACHMATOWICZ PYRANONE DISCONNECTION |
NOTES :
The synthesis of pyran-3-ones starting with furfuryl alcohols, which are first converted to dialkoxydihydrofurans by e.g.Clauson–Kaas electrochemical oxidation, followed by acid hydrolysis. There is also an aza-analogue known based on furylacetamides. See also Clauson–Kaas reaction.
ADAMS DECARBOXYLATION REACTION
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| ADAMS DECARBOXYLATION REACTION |
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| ADAMS DECARBOXYLATION DISCONNECTION |
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| ADAMS DECARBOXYLATION MECHANISM |
NOTES :
Coumarin acids (2-oxo-2H-chromene-3-carboxylic acid) are decarboxylated by heating with aqueous sodium hydrogensulfite followed by treatment with concentrated alkali or acid.
ADKINS – PETERSON FORMALDEHYDE REACTION
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| ADKINS – PETERSON FORMALDEHYDE REACTION |
NOTES :
An air methanol mixture, containing 5 – 8 % methanol vapour is passed over a metal oxide (Iron oxide, molybdenum oxide or iron molybdenum oxide) catalyst to afford 40% aqueous formaldehyde free of methanol.
ADLER – LONGO PORPHYRIN REACTION
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| ADLER – LONGO PORPHYRIN DISCONNECTION |
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| ADLER – LONGO PORPHYRIN MECHANISM |
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| ADLER – LONGO PORPHYRIN REACTION |
NOTES :
This is a very low yielding and slow reaction for the formation of porphyrins. Several improved syntheses have been published over the years. See also Lindsey, MacDonald, Rothemund and Taniguchi reactions.
